Biochemistry & Molecular Biology Letters
ISSN (PRINT): 2454-9304

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Transmitted Drug Resistance

 When an individual acquires a strain of HIV that's already immune to certain antiretroviral (ARV) drugs. The introduction of antiretroviral therapy has led to a dramatic improvement in rates of morbidity and mortality for individuals infected with HIV-1. However, the emergence of drug-resistant strains has proved a major obstacle to achieving successful treatment regimens. In particular, the phenomenon of primary or transmitted resistance, when a private is infected by a strain of HIV-1 already immune to one or more drugs, has emerged as a potential threat to the success of antiretroviral therapy. Viral fitness is defined because the overall capacity of an epidemic to infect, replicate and produce mature infectious progeny during a defined host environment. The emergence of resistance mutations within the reverse transcriptase (RT ) and protease gene during antiretroviral therapy has been shown to be associated with a reduction in viral fitness

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Citations : 18

Biochemistry & Molecular Biology Letters received 18 citations as per Google Scholar report

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