A strain to be selected for fermentation process should satisfy the subsequent criteria- it should be ready to produce the specified product and produce the merchandise at large scale, it should be a well known organism, it should be ready to grow faster, it should be safe to handle, it should grow in minimal to moderate growth media, it should have optimum growth temperature considerably above 400c, reduces the cooling costs and can be beneficial for isolation procedures at large scale fermentation processes, it should be genetically stable and straightforward to know , it should be easier to control it at genetic level, product recovery should be easy from the culture. Either pure cultures are often isolated from their natural habitats or are often acquired by order from culture collection centres. Natural habitat that we select for isolation of the specified strain should have a high biodiversity, should be unexplored and will encourage the dominance of desired microbial strain. Culture collection centre include ATCC, NCYC, JCM, NCIB etc. Strain improvement has been a breakthrough of all commercial fermentation processes. This improvement process has been achieved through mutation or by genetic recombination and selection. This process enables the microbial strains to the overproduction of desired industrial products accordingly. Strain improvement through mutations include either chemicals or radiations as mutagen .Genetic recombination includes desired strain construction, a vector, promoters, expressions systems etc. Genetically improved strains got to be identified and isolated from various microbial populations through high throughput screening methods. Finally the isolated microbes got to be stored by lyophilisation, agar slope cultures in oil at -200c etc. Open access (OA) may be a set of principles and a variety of practices through which research outputs are distributed online, freed from cost or other access barriers.With open access strictly defined (according to the 2001 definition), or libre open access, barriers to copying or reuse also are reduced or removed by applying an open license for copyright. the most focus of the open access movement is "peer reviewed research literature." Historically, this has centered mainly on print-based academic journals. Whereas conventional (non-open access) journals cover publishing costs through access tolls like subscriptions, site licenses or pay-per-view charges, open-access journals are characterised by funding models which don't require the reader to pay to read the journal's contents. Open access are often applied to all or any sorts of published research output, including peer-reviewed and non peer-reviewed academic journal articles, conference papers, theses, book chapters, and monographs.