Microbiology: An International Journal

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Microbiota Transplant

Fecal microbiota transplantation (FMT) is an infusion within the colon, or the delivery through the upper alimentary canal , of stool from a healthy donor to a recipient with a disease believed to be associated with an unhealthy gut microbiome. FMT has been successfully wont to treat recurrent Clostridium difficile infection (rCDI). The short-term success of FMT in rCDI has led to investigations of its application to other gastrointestinal disorders and extra-intestinal diseases with presumed gut dysbiosis. Despite the promising results of FMT in these conditions, several barriers remain, including determining the characteristics of a healthy microbiome, ensuring the security of the recipient with reference to long-term outcomes, adequate monitoring of the recipient of fecal material, achieving high-quality control, and maintaining reasonable costs. For these reasons, establishing uniform protocols for stool preparation, finding the simplest modes of FMT administration, maintaining large databases of donors and recipients, and assuring that oral ingestion is like the more widely accepted colono scopic infusion are issues that require to be addressed. the utilization of FMT became rapidly accepted mainly due to its success in treating rCDI. Data from several RCTs and an outsized case series revealed the efficacy and safety of FMT .A recent systematic review and meta-analysis of seven RCTs and 30 case series demonstrated the prevalence of FMT over vancomycin therapy, with resolution rates as high as 92% Moayyedi et al. showed that FMT was superior to placebo or vancomycin therapy . Fischer et al. reported that FMT clinically cured 91% of patients with severe rCDI that failed maximal medical therapy 

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