Human Amnion Epithelial Cells Open Access Articles

 An amniotic epithelial cell is a form of stem cell extracted from the lining of the inner membrane of the placenta. Amniotic epithelial cells start to develop around 8 days post fertilization. These cells are known to have some of the same markers as embryonic stem cells. Human amnion consists of amniotic epithelial cells (AECs) on a basement collagenous membrane, an acellular compact layer filled with reticular fibers, a fibroblast layer with Hofbauer cells/histiocytes, and a highly hygroscopic spongy layer with fibrils between the chorion and the amniotic sac. Based on these interesting clinical and laboratory findings, preserved AM is considered to be one of the most appropriate carrier materials for transplantation of cultivated corneal epithelial cells. Although there is still debate surrounding its use, including the merits and demerits of the denuding process for amniotic epithelial cells and controversy regarding methods, the clinical results of cultivated corneal epithelial transplantation using an AM carrier are encouraging.  

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