Abstract

Synthesis and Characterization of Substituted 5-([1,2,4] Triazolo [3,4-B][1,3,4] Thiadiazol-3-yl)-1,3-Benzoxazole Derivatives as Antimicrobial Agents

Author(s): S. Janardhan, M. Sarangapani and G. Balaswamy

In this study, a series of novel substituted 5-([1,2,4] triazolo [3,4-b][1,3,4] thiadiazol-3-yl)-1,3-benzoxazole derivatives have been synthesized and their structures were confirmed by IR, 1H NMR, and Mass spectral data. These compounds were prepared by a mixture of substituted 4-amino-5-(1,3-benzoxazol-5-yl)-4H-1,2,4-triazole-3-thiols with various carboxylic acids and phosphorus oxychloride. All synthesized compounds VII a-o were tested by using the method of cup-plate technique against certain strains of Gram-positive, Gram-negative bacteria as well as the yeasts Aspergillus niger, Aspergillus flavus, Fusarium oxysporum and Curvularia lunata in comparison with standard drugs. Microbiological results showed that the newly synthesized compounds possessed a broad spectrum of activity, compound VII d showed good antibacterial and VII j showed good antifungal activity. Rest of the compounds showed mild to moderate antifungal activity against testing organism.


Share this       
izmir escort izmir escort bursa escort antalya escort izmir escort porno porno izle türk porno eskişehir escort bartın escort burdur escort izmir escort bursa escort porno indir izle escort izmir