Synthesis and Characterization of Substituted 5-([1,2,4] Triazolo [3,4-B][1,3,4] Thiadiazol-3-yl)-1,3-Benzoxazole Derivatives as Antimicrobial Agents

Author(s): S. Janardhan, M. Sarangapani and G. Balaswamy

In this study, a series of novel substituted 5-([1,2,4] triazolo [3,4-b][1,3,4] thiadiazol-3-yl)-1,3-benzoxazole derivatives have been synthesized and their structures were confirmed by IR, 1H NMR, and Mass spectral data. These compounds were prepared by a mixture of substituted 4-amino-5-(1,3-benzoxazol-5-yl)-4H-1,2,4-triazole-3-thiols with various carboxylic acids and phosphorus oxychloride. All synthesized compounds VII a-o were tested by using the method of cup-plate technique against certain strains of Gram-positive, Gram-negative bacteria as well as the yeasts Aspergillus niger, Aspergillus flavus, Fusarium oxysporum and Curvularia lunata in comparison with standard drugs. Microbiological results showed that the newly synthesized compounds possessed a broad spectrum of activity, compound VII d showed good antibacterial and VII j showed good antifungal activity. Rest of the compounds showed mild to moderate antifungal activity against testing organism.

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