Evaluation of Anti-Fertility Activity of Ethanol Extract of Cynoglossum Zeylanicum (Vehl Ex Hornem) Thumb. Ex Lehm (Boraginaceae) Whole Plant on Male Albino Rats

Author(s): V. R. Mohan, M. Anitha, G. Sakthidevi and S. Muthukumarasamy

Anti-fertility effect of ethanol extract of whole plant extract of Cynoglossum zeylanicum was observed in male albino rats. The relative weight of the testes and epididymis were decreased. The epididymal sperm count, motility and sperm abnormality were reduced significantly in treated rats. There was an increase in serum urea, creatinine and the activity of liver marker enzymes (SGOT, SGPT and ALP) levels of plant extract treated rats. The activities of serum antioxidants (CAT, SOD, GPX, GST and GRD) in plant extract treated rats were decreased. The results of the hormonal assay showed that increased serum levels of FSH and estrogen but decreased in the serum levels of LH and testosterone compared to control. The results of fertility test indicated that the treated adult male rats reduced the number of female’s impregnation. In addition, the number of implantations and the number of viable fetuses were also decreased. The results of the present study concluded that, ethanol extract of whole plant of Cynoglossum zeylanicum inhibited sperm concentration, motility and testosterone which might result in a male sterility.

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