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Effect of Different Natural and Synthetic Superdisintegrants Used in Developement of Amiodarone Hydrochloride Fast Dissolving Tablets: A Comparative Study

Author(s): A. Abdul Hasan Sathali and M. Suganya

In the present work, fast disintegrating tablets of Amiodarone hydrochloride were prepared by subliming method with a view to enhance the patient compliance. Different natural and synthetic superdisintegrants were used in different ratio with camphor (30% W/W) as subliming agent. The prepared tablets were evaluated for various parameters like weight variation, hardness, friability, in vitro disintegration time, drug content, modified disintegration time, water absorption ratio, wetting time, in vitro dispersion time, in vitro wetting volume, measurement of tablet porosity, in vitro drug release, preliminary compatibility studies, FTIR, DSC studies, scanning electron microscopy before and after sublimation and short term stability studies. All the pre and post-compressional parameters are evaluated and found within the prescribed limits. The optimized formulation (O F5) and (H F4) showed good release profile with maximum drug being released at all time intervals. The result of the work concluded that the sublimation is a useful technique to enhance the solubility and dissolution rate of poorly water-soluble drugs. The release of Amiodarone from FDTs was found to follow non-Fickian diffusion kinetics.

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