More recently, the definition has been broadened to include biological characteristics that can be objectively measured and evaluated as an indicator to therapeutic intervention of normal biological processes, pathogenic processes/ pharmacological responses. Biomarkers sometimes serve as intermediate markers and also as drug targets in clinical trials. The process by which the biomarkers are discovered is termed as biomarker discovery. The identification of tumor biomarkers is the first step in personalizing medicine. So based on the action of bio markers, they are of different types. A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record.