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Strain Selection And Improvement Innovations

A strain to be selected for fermentation process should satisfy the subsequent criteria- it should be ready to produce the specified product and produce the merchandise at large scale, it should be a well known organism, it should be ready to grow faster, it should be safe to handle, it should grow in minimal to moderate growth media, it should have optimum growth temperature considerably above 400c, reduces the cooling costs and can be beneficial for isolation procedures at large scale fermentation processes, it should be genetically stable and straightforward to know , it should be easier to control it at genetic level, product recovery should be easy from the culture. Either pure cultures are often isolated from their natural habitats or are often acquired by order from culture collection centres. Natural habitat that we select for isolation of the specified strain should have a high biodiversity, should be unexplored and will encourage the dominance of desired microbial strain. Culture collection centre include ATCC, NCYC, JCM, NCIB etc. Strain improvement has been a breakthrough of all commercial fermentation processes. This improvement process has been achieved through mutation or by genetic recombination and selection. This process enables the microbial strains to the overproduction of desired industrial products accordingly. Strain improvement through mutations include either chemicals or radiations as mutagen .Genetic recombination includes desired strain construction, a vector, promoters, expressions systems etc. Genetically improved strains got to be identified and isolated from various microbial populations through high throughput screening methods. Finally the isolated microbes got to be stored by lyophilisation, agar slope cultures in oil at -200c etc. Innovations are new idea, device or process. Innovations are the appliance of higher solutions that meet new requirements, inarticulated needs or existing market needs. It’s proficient through simpler products, processes, services, technologies, or new ideas that are readily available to markets, governments and society. Innovation in its modern meaning is "a new idea, creative thoughts, new imaginations in sort of device or method". Innovation is usually also viewed because the application of higher solutions that meet new requirements, unarticulated needs, or existing market needs. Such innovation takes place through the supply of more-effective products, processes, services, technologies, or business models that are made available to markets, governments and society. Innovations are some things original and simpler and, as a consequence, new, that "breaks into" the market or society. Innovation is said to, but not an equivalent as, invention, as innovation is more apt to involve the sensible implementation of an invention (ie new / improved ability) to form a meaningful impact within the market or society, and not all innovations require an invention. Innovation often[quantify] manifests itself via the engineering process, when the matter being solved is of a technical or scientific nature. The other of innovation is exnovation.

 

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Biochemistry & Molecular Biology Letters received 17 citations as per Google Scholar report

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