Lysosomal Vesiculosis

When compared with the pathological hallmark of "granulo-vacuolar degenerations" in Alzheimer's disease, postsynaptic monkey neurons have been carefully examined under a microscope. Surprisingly, we found a very similar change, and we identified it as "eleosomal vesiculosis" by electron microscopy. However, the exact molecular and structural effects of Hsp70.1 disorder on the liposomal membrane are not clearly known in the human brain due to proper and ethical issues. Accordingly, using monkey brain tissues after in-vivo and in-vitro oxidative stress, we studied the molecular changes of Hsp70.1 and its counterpart bis (monoacylglycero) phosphate (BMP), as these molecules are closely related to liposomal membrane stability. Regulates  sphingomyelinase.