All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis of New Fluorine Compounds Bearing 5-Aryl-1,3-Di(Acyl/Alkyl)-6-Azauracil Derivatives as Pharmacological Probes

Author(s): Dina Abed Bakhotmah*, Reda Mohammady Abdel-Rahman, Rahma El-Nabati

New fluorine compounds bearing 5-aryl-1,3-di(trifluoroacetyl;4'-fluorobenzoyl;4'-fluorothiaanilido; methyl; substituted methyl)-6 azauracil derivatives (2-11) have been achieved derived from the interactions of 5-(2'-amino-5'-fluorophenyl)-6-azauracil (1) with α,β-bifunctional reagents in differ media and conditions. 5-Substituted-8-fluoro-1,2,4-triazino[5,6-b] indol-3(2H)ones (12-16) also produced from dehydration of compounds 2-11 by refluxing with dry acetone. Structures of the new products have been established from their elemental analysis and spectral measurements (UV, IR, 1H/13C/19F NMR and mass). These new fluorinated compounds evaluated as antioxidant agents by using DPPH and ascorbic acid as standard.

Share this       
Awards Nomination

Table of Contents