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Synthesis Characterization and Antibacterial Evaluation of Cephradine and Ceftriaxone Schiff Base Copper Complexes

Author(s): Abbas H. Abdulsada

In the present study, new Schiff bases were synthesized from condensation of cephradine and ceftriaxone with Terephthalaldehyde and their corresponding metal complexes with copper (II) have been synthesized. Assignment of Schiff bases and their copper complexes was performed by FT-IR, elemental analysis and [1] H NMR analysis. Their antibacterial activity were assessed against several bacterial strains namely S. aureus, E. coli and P. aeruginosa. The antibacterial screening tests reveal that both Schiff bases and their copper complexes counterparts exhibited promising antibacterial activity against the tested bacterial species so that they are of improved antibacterial activity than the parent drugs.

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