7187379870

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis and Antimicrobial Evaluation of some Novel Heterocyclic Compounds

Author(s): Sanjay D. Prajapati and M. K. Thakor

3-(4-Aminophenylsulfonyl)-1,3,4-oxadiazole-2(3H)-thione (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 3-(4-(substituted benzylideneamino)phenylsulfonyl)-1,3,4-oxadiazole-2(3H)-thiones (2a-e) in good yields. Cyclocondensation of compounds (2a-e) with thioglycolic acid yields 2-subsituted phenyl-3-(4-(2- thioxo-1,3,4-oxadiazol-3(2H)-ylsulfonyl) phenyl) thiazolidin-4-ones (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.


Share this