Abstract
Microbial Chemistry as a Structural Blueprint for Rational Drug Design
Author(s): Pavel I. NovákDrug design aims to create chemical entities capable of selectively interacting with biological targets to produce therapeutic effects. Microbial chemistry has become an invaluable contributor to this process by providing structurally refined and biologically active molecules that inform rational drug design strategies. Microbial metabolites often exhibit optimized molecular features shaped by evolutionary pressures, making them highly suitable as templates for chemical modification. This article explores the role of microbial chemistry in drug design, emphasizing how microbial-derived structures guide molecular optimization, target specificity, and the development of next-generation therapeutics.
