Abstract

Influence of Microbial Chemistry on Pharmacokinetics of Therapeutic Agents

Author(s): Omar S. Al-Qasimi

Pharmacokinetics describes the absorption, distribution, metabolism, and excretion of drugs within biological systems and plays a decisive role in determining therapeutic efficacy and safety. Microbial chemistry contributes significantly to pharmacokinetic behavior, particularly for drugs derived from microbial sources or processed through microbial metabolism. Microbial metabolites often exhibit unique chemical properties that influence solubility, stability, and metabolic fate. This article explores the relationship between microbial chemistry and pharmacokinetics, emphasizing how microbial-derived chemical structures and biotransformations affect drug disposition in the body.