Formulation and Evaluation of Hydrotropic Solid Dispersions of CurcuminAuthor(s): Krishna R Gupta, Anita R Pounikar, Priyanka M Jaiswal, Milind J Umekar
The hydrotropic solid dispersion may proper choice to preclude the use of organic solids so that simple, accurate and precise method could developed to enhance the solubility of poorly water soluble drugs. Solubility of curcumin is increased by using nicotinamide as a hydrotropic solid dispersing agent. Curcumin showed the maximum absorbance at 423 nm. At these wavelength, hydrotropic solid dispersing agent did not show any significant interference in the spectrophotometric study. The developed method were found to be linear in the range of 2-10 µg/ml with correlation coefficients (R) of 0.993. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical parameters were found to be good in accordance with the prescribed values. As hydrotropic solid dispersing agent was used in the proposed method, the method can be said to be eco-friendly and it can be used to increase solubility of poorly soluble drugs.