Gelatine Tannate

Gelatine tannate (GT) is a complex of tannic acid, with properties of acne, antibacterial, anti-inflammatory, and protective gelatine. It is increasingly being marketed as an antibiotic. Our aim was to review data on the efficacy of GT in the treatment of acute gastroenteritis (AGE) in children and adults. MEDLINE, EMBASE, and Cochrane Library database were searched in July 2013, with no language restrictions, for clinical controlled trials. Additional references were found in the reviewed articles. Two trials met the inclusion criteria. In adults, one randomized controlled trial involving 40 subjects (mean age: 43 ± 13 years) found that, compared with placebo, GT could be effective in reducing some of the symptoms of AGE in the first 2 h after of the initiation of treatment. In children, one negative quality study (no randomization and no blinding) involving 211 children (mean age: 2.5 ± 2.4 years) was reported with a positive effect of GT 12 hours after treatment initiation. No one in the study endorsed the effect of GT on the first actions that resulted from this review such as chair removal, diarrhoea, hospital admission, hospital stay, and (in children) weight loss after a massage. At present, there is no evidence to support the use of GT in the treatment of AGE in children and it is the only sparse evidence to support the use of GT in adults.

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