Endogenous Opioids

 Endogenous opioids are enkephalins and endorphins that are primarily produced in the brain and have multiple actions throughout the body. Enkephalins and endorphins act at opioid receptors and their activity can be blocked by opioid antagonists. As a result of MS, the detrusor muscle in the wall of the bladder involuntarily contracts, increasing the pressure in the bladder and decreasing the volume of urine the bladder can hold. This causes symptoms of going frequently, urgently, leaking urine, or interfering with a good night's sleep. As MS lesions develop, they affect transmission of nerve signals between the brain and the nerves that control the bladder and urinary sphincters. This leads to an overactive bladder that cannot hold a full capacity of urine in the patient.   

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