Abstract

Partial Reversal of T2D Through Dietary Manupulation

Author(s): LK Shankhdhar

During evolution of T2D, most pivotal factor is increasing Insulin resistance (IR). Hence any maneuver, which reduces IR shall be a step towards reversal of T2D. Researches by Roy Taylor have shown that ultra low caloric diet reduces excess fat deposited in liver, pancreas and muscles and results into better Insulin action and often total reversal of T2D. Ultra low caloric diet has poor compliance with attended risks so we planned a moderate caloric diet, 1000- 1200 calories, which is equivalent to half of usual diet. It resulted into reduction of Insulin resistance (HOMA-IR), weight, BP, Body fat% (BFP) and betterment of glycemia and lipid profile. Ten patients participated in the sturdy which lasted for 3 weeks. All were advised to take half of their usual diet. Their mean age was 57 (+/- 14.97) yrs, DOD 7.7 (+/-4.59) yrs, wt 88.6 (+/- 11.2) Kg, BFP 38.94 (+/- 3.35)%, HOMA-IR 5.6 (+/-2.04), FBG 228.3 (+/- 57.01) mg%, PPBG 339.9 (+/- 56.08) mg% and sex ratio (5M, 5F) Results: Mean change in HOMA-IR -1.8 (1.92 +/- 0,60), Wt -3.3 (2.26 +/- 0.71) Kg, BFP - 1.97 (0.98 +/- 0,31) %, SBP -29.2 (11.74 +/- 1.37) mmHg, DBP -12.8 (6.94 +/- 2.19) mmHg, Lipids (Total Chol: 35.30+/- 5.20 mg%, TG: - 49.40 +/- 10.12 mg%, LDL: -30.00 +/- 8.76 mg%) and HDL: +2.90 +/-5.40 mg%), FBG -91.5 (62.90 +/- 19.89) mg% and PPBG – 149.8 (71.96 +/- 22.75) mg% All patients revealed betterment in glycemia, Wt, BFP, IR and BP but total reversal was found in no patient as it was only partial reversal; HOMA IR reduced by approximately 31%. Need for Insulin ceased in 90% patients