Design And Microwave Assisted Synthesis Of Dual Inhibitors

Author(s): Nikam Atul, Phranil Maheta, Burange Prashant, Ranjit Kaur,M.R.Shiradkar

N-[5-(4–Amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-4-methyl-1,3-thiazol- 2-yl]benzamide (1) on condensation with chloroacetic acid, α-haloketone and benzoin furnished [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives (2), (3) and (4) respectively, while condensation with 2,3-dichloroquino xaline, carbon disulphide, aromatic carboxylic acid and aromatic carbox aldehydes yielded the cyclic products, [1,2,4] triazolo[3,4-b][1,3,4] thiadiazole derivatives (5), (6), (7), (8) respectively. The compounds have been characterized on the basis of elemental analysis and spectral data. The antibacterial and antiinflammatory activities of the compounds have also been evaluated.

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