The investigation reported in this paper deals with the theoretical study on polar molecules CO in plasma medium. In the present calculation, the electron- dipole potential is modified and to introduce the screening effects of plasma is characterized by the inverse Debye-shielding length Âï¬Â in a0 -1. The Born Eikonal Series Approximation is used to calculate the differential scattering cross sections (DCS) for low energy the rotational excitation of target molecule CO, using various values of Âï¬Â. The results obtained are compared with the theoretical calculated Mohanan S., et al results. It is observed that due to the effect of plasma screening, the DCS increases considerably near the forward direction.