The use of nanophotocatalysts supported on adsorbents is receiving substantial attention. Supporting ZnO nanoparticles with zeolites is found to be one of the best solutions to increase the efficiency of ZnO-based photocatalysts. This work was focused on simple preparation of a ZnO/Clinoptilolite (CP) (Iranian Natural Zeolite) composite catalyst by the solid state dispersion (SSD) method and Comparison of ZnO nanoparticles and ZnO/CP on the photocatalytic degradation of Triton X-100. The degradation of Triton X-100 was systematically studied by varying the experimental parameters in order to achieve maximum degradation efficiency. The obtained results demonstrated a high photocatalytic activity of nanosize zinc oxide supported on Clinoptilolite.