Infections are caused by several microorganisms, which are mostly affecting the mucosal surfaces such as gastrointestinal tract, respiratory tract, vaginal tract etc. These microorganisms are treated with anti-infective drugs based on their severity of action in the individuals. The conventional anti-infectives have short residence time at the site of application and poor bioavailability, which leads to incomplete elimination of organisms causing reoccurance and tolerance. Recently, vesicular mode of delivery of drugs has gained attraction because of its improved therapeutic efficacy and stability. Vesicles are bilayered structures formed by hydration of lipid molecules and can be used for incorporating both hydrophilic and lipophilic drugs. This paper focus on various vesicular systems such as liposomes, niosomes, ethosomes, transferosomes and their contribution towards overcoming the disadvantages of anti-infective drugs.