Abstract

Trimethyl phosphite mediated simple synthesis of coumarins and azachromenes through the reaction of phenols and dimethyl acetlendicarboxylate

Author(s): Allahdad Shababi, Reza Shababi, Mahmood Payehghadr

Protonation of the reactive intermediates produced in the reaction between Trimethyl Phosphite and dimethyl acetylenedicarboxylate by resorcinol 5- methylresorcinol 2,5 -dihyroxyasetophenone, 4 - chlro - 2 -methvlphenol, 2 - hydroxypyridine, or 4 - hydroxypyridine - leads tovinylphosphoniumsalts, which undergo michail addition with the conjugate basi of the OH-acid to produce functionalized 2-oxo-2H-chromenes (coumarins) and azachromenes in good yields.


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