Time of Arrival (TOA) estimation used with impulse-radio ultra-wideband transmission is currently the most popular technique for accurate localization. TOA estimation based energy-detection (ED) is a very feasible technology for sub-Nyquist sampling rate and no requirements on the knowledge of the signal shape,Nevertheless,this method is vulnerable to the interference of noise and other wireless systems. This paper presents a method based independent component analysis (ICA) to mitigate the interference. ICA can separate various kinds of source signals,according to the principle of these source signals statistical independence,then we estimate TOA from the extracted UWB signals. Compared with other two traditional ED estimators:Multiscale Energy Products and EDadaptive estimator via simulation,we demonstrate that the proposed TOA estimation has superior performance,and it is a very good method for interference suppression in IRUWB systems.