Chromones are found to be natural or natural origin. Several studies have been performed on the types of reagents utilized for the cyclization of chalcones to chromene-4-ones. Chromones are recognized as pharmacophores having a number of biological activities such as anticancer, antiviral, antifungal, antimicrobial, antioxidant, antidepressant and antiobesity etc. There are various synthetic methods reported. Therapeutic potential and brief discussion on synthesis of chromones are reviewed.