Various hot brand reactive dyes have been prepared by coupling tetrazotised 4, 4’-methylene-biso- bromo aniline with various m-toluidino cyanurated coupling components and their dyeing performance as reactive dyes has been assessed on silk, wool and cotton fibres. The purity of all dyes has been checked by TLC. All the dyes were characterized by their percentage yield, UV-Visible spectra, elemental analysis, IR and 1H-NMR spectroscopy. The percentage dye bath exhaustion of different fibres has found to be good and acceptable. The dyed fibres show fair to very good fastness to light, wash and rubbing. All the synthesized dyes have been screened for their antimicrobial activity.