Huge quantity of fishery wastes and by-products generated every year either doesnÂt been utilized properly or simply dumped in the sea to lead environmental issues. The discarded wastes are rich source of protein that can be made use in various commercial and industrial applications. The protein hydrolysate recovered from various fishes and fish parts were shown to have antioxidant, antihypertensive, immunomodulatory, neuroactive, and antimicrobial properties. The chemicalmethods used for the protein recovery does not produce the yield with required standards. Thus enzymatic recovery of protein hydrolysate is preferred choice and this technique is gainingmomentumnow. The present study was designed to produce a protein hydrolysate from the skin of Scomberomorus commerson by tryptic digestion. The results showed that the enzyme was capable to recover considerable quantity of protein and the protein hydrolysate prepared was undergone good degree of hydrolysis. Thus the protein hydrolysate of the skin of Scomberomorus commerson is a promising candidate for further characterization.