Synthesis of a novel class of 1,ù-bis/(hydrazides), (hydrazones), (1,3,4-oxadiazoles) and (1,3,4-thiadiazoles)with potential antimicrobial activity

Author(s): Nasser S.A.M.Khalil

A series of novel class of 1,-bis/ (carboxylic acids), (esters), (hydrazides), (hydrazones), (1,3,4-oxadiazoles) and (1,3,4-thiadiazoles)were synthesized. Of these novel compounds, some were seleced and evaluated for their antimicrobial activity against different strains ofGram-positive bacteria (Bacillus subtilis RCMB 101-001 and Staphylococcus aureus RCMB 106- 001 (1)), Gram-negative bacteria (Pseudomonas aeruginosa RCMB 102- 002, Escherichia coli RCMB 103-001 and Salmonella typhi RCMB B 008 001), yeast (Candida albicans RCMB 005003) and fungi (Aspergillus fumigatus RCMB 002008 (1), Penicillium italicum RCMB 001018 (1) and Syncephalastrum racemosum RCMB 016001). The screening results revealed that all the tested compounds exhibited broad spectruminhibitory effects against different microbes. Some tested compounds showed remarkable higher activities against some test organisms, when compared to Chloramphenicol as commersial standard antibacterial agent and Terbinafin as commersial standard antifungal agent (at concentration 0.5 mg/mL).

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