Abstract

Synthesis and biological evaluation of 1,3,5-triazine based chalcones and their derivatives

Author(s): Kishor Kapadia, Hiral Patel, Yogesh Prajapati, Pankit Solankee, Sejal Solankee, Anjani Solankee

Chalcones, 2,4-bis-(4’-chlorophenylamino)-6-[4’-{3’’-(substituted phenyl/ 2’’’- thienyl/2’’’-furanyl/cinnamyl)-2’’-propenon-1’’-yl}phenyl amino]-striazines( 6a-d) have been prepared from ketone (5) based on s-triazine nucleus. These chalcones (6a-d) on cyclisation with guanidine nitrate in presence of alkali, malononitrile in presence of ammonium acetate and hydrazine hydrate in presence of glacial acetic acid give the corresponding aminopyrimidines (7a-d), cyanopyridines (8a-d) and acetylpyrazolines (9a-d) respectively. The structures of newely synthesized compounds have been confirmed on the basis of elemental analysis, IR and 1H NMR spectral data. They are also tested for their antibacterial activity.


Share this