Some new Schiff’s base of methyl sulphamido-7-hydroxy-4-methyl coumarin were synthesized and the anti nociceptive and in vitro anti-inflammatory activities were evaluated. The Mannich reaction between 7-hydroxy-4-methyl coumarin, sulphanilamide and formaldehyde gives 7- hydroxy-4-methyl-8[sulphamidomethyl] coumarin (1). The compound (1) with various aromatic aldehydes gives Schiff’s base (2a-2g). All the synthesized compounds were characterized by spectral analysis. The in vitro anti-inflammatory activity was carried by HRBC membrane stabilization method and the antinociceptive activity was carried by Writhing reflux method and hot plate method. All the compounds shows significant anti-inflammatory and anti-nociceptive activity.