Some of the biphenyl compounds were synthesized and these compounds were screened for the antibacterial activity. The derivatives were synthesized using different substituted amines to the chloro biphenyl derivative. All the compounds were characterized using IR and NMR data. The antibacterial activity were screened against gram positive organism like Bacillus subtilis & Staphylococcus epidermidis and gram negative organism against E. Coli & Pseudomonas aeruginosa. All the compounds show a moderate to good activity against the selected strains.