We feed gelatin peptide to fatigue mice for nutrition intervention, detect and evaluate the effect of gelatin peptide to delay and moderate of central fatigue. We want to develop the high value-added products of pigskin gelatin bioactive peptide, expense the scope of use of the product. Compare to the control group of feeding double distilled water, DA/5-HT of animal experimental group is 0.84, control group is 0. 14. Comparison of these two groups, the experimental group is 600% higher than the control group. Gelatin peptide has obviously increased the effect of central excitatory, alleviated the central fatigue.