100 meters race is one of the movement project, which carried out is earlier, own characteristics of Encourage competition, and Ornamental. Now, there are many factors that influence the evolution of 100 meter world records, For example doping, which is most representative. Since human society entered in 21st Century, the event that about 100 meters running stimulant abuse always happen. For example, the men's 100 meters world record holder, Jamaica’s Boulter, constantly refresh men's 100 meters world record. Many Authoritative sources suspicion on Boulter use the Doping to keep men's 100 meters world record. However, experts in medical field declared: “Doping is useless in 100 meter race." this paper base on the development process about 100 meters world record and characteristics, analysis the influence of doping in the 100 meters world race in evolution, and puts forward some opinions and suggestions.