The Aqueous, dichloromethane-methanol and pet. ether extract of the latex of Euphorbiatirucalli L. (Euphorbiaceae) was screened for analgesic and anti-inflammatory activities. Analgesic activity was compared with aspirin by tail-immersion and by acetic acid induced writhing methods. The anti-inflammatory activity against carrageenan induced paw edema in albino rats was compared with ibuprofen. In all the methods encouraging results were obtained for aqueous, dichloromethane-methanol and pet. ether extracts.