To evaluate the pricipal epidemiological and evolutive characteristics of Stevens Johnson Syndrome. A retrospective descriptive study was con- ducted of all cases of Steven Johnson Syndrome was notified to Moroccan Center Anti Poison and Pharmacovigilance by professionals health be- tween the period January 2010 and December 2012. During this period, 23 cases of Steven Johnson Syndrome have been reported an average of 8 cases / year. Women are the most affected (sex ratio (F / M = 2.2). The most incriminated drugs were: Allopurinol (21%), Ethambutol, Isoniazid/Rifampi- cin, Pyrazinamide paracetamol, sulfamethoxazole / trimethoprim 5% each. The causality according to WHO method showed that 62% were probable and possible in 38% of cases. The outcome was favorable in 86% of cases, one case was fatal and 9% of cases, have not been not been specified.