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Abstract

Stability-indicating bivariate spectrophotometricmethod for determination of candesartan cilexetil in presence of its alkaline induced degradation product application to tablets and content uniformity testing

Author(s): Nawal Al-Arfaj, WedadAl-Onazi, Amina Al-Brashy

A simple, sensitive, selective and precise stability-indicating method for the determination of candesartan cilexetil (CC) in presence of its alkaline degradate and in tablets was developed and validated. The method is based on determination of CC by the bivariate calibration depending on simple mathematic algorithm which provide simplicity and rapidity. The method showed good linearity in the range of 1-12 µg mL-1 at 225 and 2-12µgmL-1 at 250 nmwithmean percentage recovery 100.29±0.64.CC can be determined in the presence of up to 80 % of its alkaline degradate, the selectivity of the method was checked using laboratory prepared mixtures. The proposed method has been successfully applied to the analysis of CC in bulk and in commercial tabletswithout interference fromadditives or excipients and the results were satisfactory compared with a reference method.Also, the suggested method was successfully applied to the content uniformity testing.


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Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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