Mizolastine is an antihistamine drug. Three simple, sensitive and accurate spectrophotometric methods have been developed for the determination of mizolastine in pure state and in its pharmaceutical dosage forms. The method A is based on the complex formation of the drug with cobalt thiocyanate and the developed chromogen in method A exhibits maximum absorption at λmax 620 nm and linearity in the range of 20-100 µg/mL. The developed method B is based on ion association complex formation between the drug and methyl orange to produce colored chromogen having maximum absorption at λmax 420 nm. Beer’s law is obeyed in the range of 10-50 µg/mL. Method C is based on ion association complex formation of the drug with bromothymol blue to form colored chromogen and it shows maximum absorption at λmax 415 nm and linearity in the range of 2-10 µg/mL. Results of analysis were validated statistically and by recovery studies.