Two simple, rapid and accurate methods have been developed for the estimation of itopride and rabeprazole in the mixture. Itopride has absorbance maxima at 257.5 nm and rabeprazole has absorbance maxima at 292 nm in 0.01N NaOH. The linearity range was observed in 5-252g/mL for itopride and rabeprazole. First method is based on simultaneous equation and second method is based on Q absorbance ratio. Absorbances at isoabsorbtive point 271.9 nm and at 8max of rabeprazole were measured for Q absorbance ratio method. These methods were validated statistically. The recovery study confirmed the accuracy of proposed methods.