Abstract

Simultaneous Estimation of Amlodipine and Atorvastatin in Tablets using Orthogonal Function Ratio Spectrometry

Author(s): A. Kottai Muthu, T. Rattaiah Gupta, Shailesh Sharma, A. Anton Smith, R. Manavalan and N. Kannappan

Orthogonal polynomial function method has been developed for the simultaneous estimation of binary mixtures of Amlodipine and Atorvastatin in tablet formulations. All the parameters for orthogonal polynomial function method have been optimized by using computer programme in “C” language. The
described method was applied for the determination of these combinations in synthetic mixtures and tablet dosage forms. The contents of amlodipine in tablets were found to be 2.49 mg and Atorvastatin is 9.96 mg of the label claim 2.5 mg of amlodipine and 10 mg of Atorvastatin respectively. The linearity
was validated by least square method. The recovery is within the limit of 98% to 102%. The proposed methods are simple, economical, accurate, reproducible and rapid.

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