In this study, the effect of Shi-He-Powder (SHP) on remitting weaning stress of piglet was observation. Each of four treatment groups’ piglets were respectively feed by basal diet (control group), and the basal diet add into1 fold SHP (1SHP group), 0.5 fold SHP (0.5SHP group), and 2 fold SHP (2SHP group). The behavior change, feed intake, weight gain and blood routine were observed, the expression of Inflammatory factors were detected by ELISA and RT-PCR, and HE staining was used to observe histology of the liver and jejunum. The result shows that the weaned stress will cause diarrhea and other adverse effects to the piglets. But comparing control group, SHP treatment can relieved diarrhea, significantly increased daily gain (P < 0.05), and decreased feed conversion ratio (P < 0.05); the tissue morphology of liver and the top of jejunum villi were more complete than control group. The SHP treatment can decreased the expression of IL-1β, IL-6, iNOS and PGE2, but have no significant different with TNF-α. This study demonstrate that weaning stress can cause diarrhea and other adverse effects, and SHP can effectively relieve these phenomenon, and increased daily gain, decreased feed conversion ratio. The mechanism of SHP may is that SHP can play a role in against body inflammatory reaction and protect liver and intestinal from stress injure, ultimately promote digestive absorption and dynamiting to piglet.