A simple, rapid and reproducible high performance reversed phase liquid chromatographic method has been developed for the estimation of cefprozil in bulk drug sample and pharmaceutical dosage forms using RPC-18 column. The mobile phase consists of mixture of trifluoroacetic acid in water (75 volume), trifluoroacetic acid in acetonitrile (25 volume) and diluent (phosphate buffer) in the ratio of 60 : 40, respectively and was pumped at 1.0 mL/ min at 40ºC. The detection was carried out at 290 nm and the calibration curve was linear in the range of 0.2 μg/ mL to 20 μg/ mL. The method was statistically validated for its linearity, precision and accuracy. The intra- and inter-day variation was found to be less than 1% showing high precision of the assay method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determining cefprozil in bulk drug samples or in pharmaceutical formulations.