Chalcones are important precursors of flavonoids and isoflavonoids. Naturally occuring and synthetic chalcones show various biological effects, e.g. anti-inflammatory, antitumour, antibacterial, antituberculer, antiviral, antiprotozoal, gastroprotective, and others. Chalcones are lead compounds for the discovery of antioxidant, anti-inflammatory, antitumour and antiinfective agents. This review highlights recent developments of chalcones with antiinfective properties.