Hepatoprotective effect of Solanum nigrum has been studied on CCl4 induced lipid peroxidation and reduced glutathione content in rat liver homogenate. In vitro experiments show significant reduction in the malanodialdehyde (MDA) reduced by 0.1 mM CCl4. Glutathione content was almost maintained to normal in drug treated rats. Oral treatment of drug upto 3 mL/100 g body weight for 15 days did not show any rise in serum SGOT and SGPT. On similar doses, significant choleratic effect was observed without any adverse effect.