Pisonia grandis R. Br (Nyctaginaceae) is widely distributed throughout India and is a widespread evergreen tree commonly known as ‘Leechaikottaikeerai’. Leaves, stems and roots of this species are extensively used by the tribals in the preparation of several folk medicines. The plant is traditionally used as anti-rheumatic and antifungal. This plant is also pharmacologically studied for its anti-fungal, antioxidant, anti-microbial, anti-inflammatory, anti-diabetic, diuretic, analgesic and wound healing properties. This paper includes the GC-MS analysis of methanolic extract of the plant extract and phytochemical preliminary analysis of the plant Pisonia grandis R. Br.