Photodynamic therapy (PDT) is a clinically accepted treatment; it is a minimally invasive treatment. PDT process is toxic activity toward malignant cells. In, PDT process photosensitizer agent absorbs irradiated light and generates singlet oxygen. Singlet oxygen directly reacted with tumor cell and damages the cell membranes. PDT is a selectively treat malignant cell during early stage confirmed by clinical investigations. PDT significantly extend the lifetime of inoperable tumor affected persons. PDT has minimum toxicity, reduced systemic effects, highly reduced long-term morbidity, excellent cosmetic as well as organ function-sparing effects of PDT treatment make it a valuable therapeutic for combination treatments. In future PDT has the potential to become effective method for cancer treatment.