Our study aimed to evaluate antimicrobial, antioxidant and antitumor activities and currently phenolic of polar extract of carica papaya leaves. Nine phenolic compounds were isolated from carica papaya leaves and identified as flavonol, flavonol glycosides, and phenolic acids. The antioxidant activity was measured by 2, 2' - Diphenyl Picrylhydrazyl (DPPH) radical scavenging method. The methanolic extract completely inhibited DPPH at three different concentrations 19, 38, 77 µl which showed very high antioxidant capacity, which was close to ascorbic acid standard use.Antimicrobial activities of plant extracts were studied against five bacterial strains and five fungal species, 0.1ml of plant extract (10mg / 1ml) had inhibitory effect for most bacterial spp. and some for all fungal spp., and clearly inhibitory effect against all of the tested strains at 0.3ml (10mg /1ml) of the extract, the inhibitory effect increase with increasing the concentration of the phenolic extract.