The standard of the development of the society is "sustainable development", which applied to all fields, whatever it is economic, political or regional tourism. This paper discusses sustainable development of regional tourism and related issues. Sustainable development is an inevitable choice of regional tourism. Ecological balance is the premise to achieve sustainable development of regional tourism as well as the basis of putting in place the sustainable development system of regional tourism. Sustainable development must follow three principles, namely: fairness principle, sustainability principles, communality principle, on which the sustainable development of regional tourism system relies to build up.