Non-alcoholic fatty liver (NAFLD) is a serious chronic diseasesï¼Âwhich harms to public health seriously. The article analyzes the risk factors for NAFLD. The evidences have shown that the drug treatment is unclear. Exercise therapy can Prevent NAFLD is accepted, which is the gold en standard for the treatment of NAFLD. Appropriate ways of exercise, intensity of exercise, time of exercise, frequency and duration of exercise, amount of exercise can ensure effectiveness of exercise therapy. Some basic scientific data is still lack of Evidence-based medicine on exercise therapy of NAFLD. We must further research on the clinical trials.