Sockeye salmon oil (SSO) is one of the richest natural sources of Omega 3. This oil also contains high amounts of astaxanthin, a strong antioxidant molecule. In the present work the physico-chemical properties of wild Alaskan Sockeye Salmon Oil were explored by NMR. The antioxidant propertieswere assessed by ESR in oldmice brain (24month) after 4 weeks feeding 100 µl/mouse, 5 Days/Week with Sockeye Salmon Oil. SSO exhibits interesting physicochemical and antioxidant properties: in aqueousmedium, SSO forms unilamellar or multilamellar droplets, and exhibits specific interactions with sphingomyelin (lowering of transition phase) and phosphatidylserine (fluidizing effect)membranes. Preliminary tests performed on aged mice showed a noticeable enhancement in health status (shinier fur, bitemarks,weight, explorative activity...) of chronicallySSOfed subjects, while ESR analysis found a decrease in the oxidative stress. The possible link between health status and a decrease of the local oxidative stress in brain upon SSO supplementation is discussed in terms of nutriprevention inAlzheimer disease.